Potassium Carbonate → HCID 22506953, 화합물

HRID 985396노트

반응식

HRID 985396 반응식
[F:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[SH:9].Cl[N:11]1[CH:16]=[CH:15][CH:14]=[C:13](Cl)[NH:12]1.[C:18](=O)([O-])[O-:19].[K+].[K+]>CC(C)=O>[Br:8][C:6]1[CH:5]=[CH:4][C:3]([S:9][C:16]2[N:11]=[N:12][C:13]([O:19][CH3:18])=[CH:14][CH:15]=2)=[C:2]([F:1])[CH:7]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 22028949HCID 22028949, 화합물HCID 225069554-Bromo-2-fluorobenzene-1-thiol

생성물 1

HCID 22506953HCID 22506953, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 2-fluoro-4-bromothiophenol (300 mg), 2,6-dichloro-pyridazine (149 mg), potassium carbonate (400 mg) and acetone (6 mL) was prepared and refluxed for two hours. The acetone from the mixture was evaporated and the resulting residue was dissolved in a solution of methanol (3 mL) and sodium metal (166 mg). The resulting solution was refluxed for 1 hour. Evaporation of methanol afforded 3-(4-bromo-2-fluoro-phenylsulfanyl)-6-methoxy-pyridazine, which was not isolated but was immediately used in Step 2.

후처리

  1. customwas prepared
  2. temperaturerefluxed for two hours
  3. customThe acetone from the mixture was evaporated
  4. dissolutionthe resulting residue was dissolved in a solution of methanol (3 mL) and sodium metal (166 mg)
  5. temperatureThe resulting solution was refluxed for 1 hour
  6. customEvaporation of methanol

출처 및 근거

ORD 기록
ord-fb71e51aa19b485a8183d2f89ebdf30c
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06872722B2

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