Trifluoroacetic acid → Ethyl 2-(6-(methylamino)pyridin-2-yl)acetate
반응식
C(O[N:6]([C:10]1[N:15]=[C:14]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:13]=[CH:12][CH:11]=1)[C:7](C)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH3:7][NH:6][C:10]1[N:15]=[C:14]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:13]=[CH:12][CH:11]=1참가 물질
4
실험 절차
To a solution of ethyl 2-{6-[(tert-butoxy)-N-methylcarbonylamino]-2-pyridyl}acetate (3.56 g, 12.1 mmol) in dichloromethane (15 ml) was added trifluoroacetic acid (8 ml). The reaction was stirred for 16 h. The solvent was removed under vacuum and the crude product was chromatographed over silica gel to yield 2.2 g (100%) of Ethyl 2-[6-(methylamino)-2-pyridyl]acetate.
후처리
- customThe solvent was removed under vacuum
- customthe crude product was chromatographed over silica gel
출처 및 근거
- ORD 기록
- ord-fe756ca3d2c144cfbc76617fb511544d
- 출처 데이터셋
- uspto-grants-2005_03
- 특허 번호
- US06872730B2
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