Thymidine, 5'-azido-5'-deoxy- → 5'-Amino-5'-deoxythymidine

HRID 985634노트

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HRID 985634 반응식
[N:1]([CH2:4][C@H:5]1[O:9][C@@H:8]([N:10]2[CH:18]=[C:16]([CH3:17])[C:14](=[O:15])[NH:13][C:11]2=[O:12])[CH2:7][C@@H:6]1[OH:19])=[N+]=[N-]>CO.[H][H]>[NH2:1][CH2:4][C@H:5]1[O:9][C@@H:8]([N:10]2[CH:18]=[C:16]([CH3:17])[C:14](=[O:15])[NH:13][C:11]2=[O:12])[CH2:7][C@@H:6]1[OH:19]

참가 물질

4

반응물 1

HCID 451456Thymidine, 5'-azido-5'-deoxy-

생성물 1

HCID 653115'-Amino-5'-deoxythymidine

시약·촉매·용매 2

HCID 178418361HCID 178418361, 화합물촉매HCID 887Methanol용매

실험 절차

The thus-obtained 5′-azido-5′-deoxythymidine was then dissolved in methanol and reduced with hydrogen using 10% palladium/carbon as a catalyst, whereby 5′-amino-5′-deoxythymidine was obtained. Yield 1.734 g, 71.6%.

출처 및 근거

ORD 기록
ord-0ebf3c2fc8c347798e750b9ed672c3a4
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06872809B2

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