Methyl Ethyl Ketone → 2-(3,5-Dimethylbenzyl)-butan-2-ol

HRID 985905

반응식

HRID 985905 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[CH2:5][Mg]Cl.[Mg].CC1C=C(C=C(C)C=1)CCl.[CH2:23]([C:25]([CH3:27])=[O:26])[CH3:24]>C(OCC)C>[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[CH2:5][C:25]([OH:26])([CH2:23][CH3:24])[CH3:27]

참가 물질

6

반응물 4

HCID 6569Methyl Ethyl KetoneHCID 1377003,5-Dimethylbenzyl chlorideHCID 5462224MagnesiumHCID 178424989HCID 178424989, 화합물

생성물 1

HCID 201586592-(3,5-Dimethylbenzyl)-butan-2-ol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

3,5-dimethylbenzylmagnesium chloride was manufactured from 2.6 g of magnesium powder and 15.5 g of 3,5-dimethylbenzyl chloride dissolved in 200 ml of diethyl ether and reacted with 7.5 g of methyl ethyl ketone in a temperature range of from 20° C. to 25° C. After 2 hours, the whole was poured onto ice and acidified, and the organic phase was separated off and extracted by shaking with water and sodium bicarbonate solution. After drying the organic phase with solid potassium carbonate, fractional distillation was carried out. 13 g of end product were obtained in a temperature range of from 63° C. to 65° C. at 0.12 mbar.

후처리

  1. additionthe whole was poured onto ice
  2. customthe organic phase was separated off
  3. extractionextracted
  4. customAfter drying the organic phase
  5. distillationwith solid potassium carbonate, fractional distillation
  6. custom13 g of end product were obtained in a temperature range of from 63° C. to 65° C. at 0.12 mbar

출처 및 근거

ORD 기록
ord-c5cf898648e64a9ba7ebd5dade721ba4
출처 데이터셋
uspto-grants-1987_12
특허 번호
US04710316

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