Isatoic Anhydride → 2-Amino-N-[4-(1H-imidazol-1-yl)butyl]benzamide
반응식
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[N:13]1([CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])[CH:17]=[CH:16][N:15]=[CH:14]1>C(O)C>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:22][CH2:21][CH2:20][CH2:19][CH2:18][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1)=[O:4]참가 물질
4
실험 절차
A mixture of 1.63 g of isatoic anhydride, 1.39 g of 1H-imidazole-1-butanamine and 25 ml of ethanol was stirred at room temperature for 22 hours. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate and cooled. The desired product was isolated by filtration, mp 91°-93° C.
후처리
- concentrationThe reaction mixture was concentrated
- dissolutionthe residue was dissolved in ethyl acetate
- temperaturecooled
출처 및 근거
- ORD 기록
- ord-8c0eb5e0a01b416bb371fb7937deb964
- 출처 데이터셋
- uspto-grants-1987_12
- 특허 번호
- US04710502
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