Trimethyl orthoacetate → HCID 14232984, 화합물

HRID 985955노트

반응식

HRID 985955 반응식
[NH2:1][C:2]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:3]=1[C:4]([NH:6][CH2:7][CH2:8][CH2:9][N:10]1[CH:14]=[CH:13][N:12]=[CH:11]1)=[O:5].[C:20](OC)(OC)(OC)[CH3:21]>C(O)C>[Cl:19][C:16]1[CH:15]=[C:3]2[C:2](=[CH:18][CH:17]=1)[N:1]=[C:20]([CH3:21])[N:6]([CH2:7][CH2:8][CH2:9][N:10]1[CH:14]=[CH:13][N:12]=[CH:11]1)[C:4]2=[O:5]

참가 물질

4

반응물 2

HCID 15050Trimethyl orthoacetateHCID 135889602-Amino-5-chloro-N-[3-(1H-imidazol-1-yl)propyl]benzamide

생성물 1

HCID 14232984HCID 14232984, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2.79 g of 2-amino-5-chloro-N-[3-(1H-imidazol-1-yl)propyl]benzamide, 5 ml of trimethyl orthoacetate and 10 ml of ethyl alcohol was heated at reflux for 24 hours. The resulting solution was concentrated and the residue was triturated with ether and gave a solid. The ether was decanted and the solid was dissolved in ethyl acetate and allowed to stand. The precipitate was collected and gave 650 mg of the desired product as tan crystals, mp 190°-192° C.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 24 hours
  3. concentrationThe resulting solution was concentrated
  4. customthe residue was triturated with ether
  5. customgave a solid
  6. customThe ether was decanted
  7. dissolutionthe solid was dissolved in ethyl acetate
  8. customThe precipitate was collected

출처 및 근거

ORD 기록
ord-8fa131882a6140489464c49bb5ce5904
출처 데이터셋
uspto-grants-1987_12
특허 번호
US04710502

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