Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 6-Bromo-2-methoxyquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) | HCID 2735153 | — |
| 반응물 | 6-Bromoquinolin-2(1H)-one | HCID 12378943 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 6-Bromo-2-methoxyquinoline | HCID 10657538 | — |
반응 단계
A mixture of 6-bromo-2-[1H]-quinolone (2.90 g) and trimethyloxoniumtetrafluoroborate (2.10 g) was stirred in dichloromethane (50 cm3) for 48 hours under nitrogen. Aqueous 10% sodium hydroxide (20 cm3) was added and the aqueous phase was extracted with dichloromethane (2×40 cm3). The dried (MgSO4) extracts were evaporated and the residue was crystallised from petroleum ether (b.p. 60°-80°) to yield 2-methoxy-6-bromoquinoline, m.p. 90°-94°, (2.16 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04710507 |
| 출처 데이터셋 | uspto-grants-1987_12 |
| ORD ID | ord-199d7d70815b4cc98a0cae6d0606db50 |
| 출처 메모 | uspto-grants-1987_12 |