Sodium Methoxide → 6-Bromo-3-cyano-2-methoxyquinoline

HRID 986008노트

반응식

HRID 986008 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](Cl)[C:6]([C:13]#[N:14])=[CH:5]2.[CH3:15][O-:16].[Na+]>CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:16][CH3:15])[C:6]([C:13]#[N:14])=[CH:5]2

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 170398056-Bromo-2-chloroquinoline-3-carbonitrile

생성물 1

HCID 142209686-Bromo-3-cyano-2-methoxyquinoline

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 6-bromo-2-chloro-3-cyano-quinoline (1.2 g) in methanol (30 cm3) was heated under reflux for 16 hours with sodium methoxide [made from sodium (0.116 g) and methanol (20 cm3)]. The mixture was cooled to 0° and the solid filtered to afford 6-bromo-3-cyano-2-methoxyquinoline, m.p. 172°-174°, (0.60 g).

후처리

  1. temperatureThe mixture was cooled to 0°
  2. filtrationthe solid filtered

출처 및 근거

ORD 기록
ord-10b48fe34e5946eeb3588d7bfce1a5e7
출처 데이터셋
uspto-grants-1987_12
특허 번호
US04710507

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