Acetic Acid → Isopropyl 2-phenyl-4-quinolone-6-carboxylate

HRID 986239

반응식

HRID 986239 반응식
N[C@H:2]([CH:7]=O)[CH2:3]CSC.[C:9]1([C:15]2[CH2:24][C:23](=[O:25])[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([C:26]([OH:28])=[O:27])[CH:21]=3)[N:16]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(O)(=O)C>C(O)(C)C>[C:9]1([C:15]2[CH2:24][C:23](=[O:25])[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([C:26]([O:28][CH:2]([CH3:7])[CH3:3])=[O:27])[CH:21]=3)[N:16]=2)[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 446793Methionin ALHCID 704325112-Phenyl-4-quinolone-6-carboxylic acid

생성물 1

HCID 70432651Isopropyl 2-phenyl-4-quinolone-6-carboxylate수율 78.8%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

Metal sodium (0.33 gram) is dissolved in 40 ml of anhydrous isopropyl alcohol and the solution is heated to reflux for one hour with 2 grams of the 2-phenyl-4-quinolone-6-carboxylic acid obtained in Example 2. After cooling, the solution is mixed with ice water, acidified with acetic acid, the crystals which separate out therefrom are collected by filtration. The crystals are washed with water, washed with methanol, and dried to give 0.6 gram of isopropyl 2-phenyl-4-quinolone-6-carboxylate, colorless powder, melting at above 300° C.

후처리

  1. temperaturethe solution is heated
  2. temperatureAfter cooling
  3. customthe crystals which separate out
  4. filtrationtherefrom are collected by filtration
  5. washThe crystals are washed with water
  6. washwashed with methanol
  7. customdried

출처 및 근거

ORD 기록
ord-ec7b457643e94d7f8fa23723661d1b4e
출처 데이터셋
uspto-grants-1987_12
특허 번호
US04711898

연결된 노트

불러오는 중…