Thiophenol → Ethyl Fluoro(phenylthio)acetate
반응식
CC[O-].[Na+].[C:5]1([SH:11])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[F:12][CH:13](Br)[C:14]([O:16][CH2:17][CH3:18])=[O:15]>O1CCCC1>[F:12][CH:13]([S:11][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[C:14]([O:16][CH2:17][CH3:18])=[O:15]참가 물질
5
실험 절차
To 150 ml of tetrahydrofuran (THF) were added 6.5 g (0.1 mole) of pulverized EtONa and 11.1 g (0.1 mole) of thiophenol and the mixture was refluxed for 10 minutes. Thereto was added 18.5 g (0.1 mole) of ethyl fluorobromoacetate and the mixture was refluxed for one hour with stirring. THF was removed by an evaporator and the precipitated NaBr was filtered. The organic layer was washed with water, dried and distilled to obtain 19.2 g (90%) of ethyl fluoro(phenylthio)acetate.
후처리
- temperaturethe mixture was refluxed for 10 minutes
- temperaturethe mixture was refluxed for one hour
- customTHF was removed by an evaporator
- filtrationthe precipitated NaBr was filtered
- washThe organic layer was washed with water
- customdried
- distillationdistilled
출처 및 근거
- ORD 기록
- ord-034b39cd848445a797046d51f9e66e48
- 출처 데이터셋
- uspto-grants-1987_12
- 특허 번호
- US04713469
반응 노트
불러오는 중…