Furan-3-carbohydrazide → HCID 178527770, 화합물

반응식

[O:1]1[CH:5]=[CH:4][C:3]([C:6]([NH:8][NH2:9])=O)=[CH:2]1.Cl[C:11]1[CH:12]=[CH:13][C:14]([C:20]#[N:21])=[C:15]([N:17]=[C:18]=[S:19])[CH:16]=1>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:21]=[C:20]3[N:9]([C:18]([SH:19])=[N:17][C:15]4[CH:16]=[CH:11][CH:12]=[CH:13][C:14]=43)[N:8]=2)=[CH:2]1

참가 물질

반응물 2

HCID 12292748Furan-3-carbohydrazide

HCID 20157506HCID 20157506, 화합물

생성물 1

HCID 178527770HCID 178527770, 화합물

실험 절차

As in Example 39, 3-furoic acid hydrazide is reacted with 5-chloro-2-cyanophenyl isothiocyanate to produce 2-(3-furyl)-5-mercapto-[1,2,4]triazolo[1,5-c]quinazoline, mp>300°, which is converted to the 5-methylthio compound and thence to 9-chloro-2-(3-furyl)-5-imino-5,6-dihydro[1,2,4]triazolo[1,5-c]quinazoline, purified as the methanesulphonate salt, mp 290°-292°.

출처 및 근거

ORD 기록: ord-f9bb581aa134498392da13d6677f2341
출처 데이터셋: uspto-grants-1987_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04713383

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