Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diphenyl Ether → Ethyl 6-methyl-5-phenyl-4-oxonicotinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diphenyl Ether | HCID 7583 | — |
| 반응물 | Diethyl (aminomethylidene)propanedioate | HCID 226751 | — |
| 반응물 | Benzene, (2,2-dimethoxypropyl)- | HCID 12282854 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Ethyl 6-methyl-5-phenyl-4-oxonicotinate | HCID 67483630 | — |
반응 단계
25 g. of diethyl aminomethylenemalonate, 18 g. of phenylacetone dimethylketal, 300 ml. of dry diphenyl ether and 1.0 g. of TSA.H2O were mixed and heated under a nitrogen atmosphere at 135°-145° C. for three hours. The mixture was then brought to reflux. After 30 minutes the solution was cooled and extracted with 200 ml. of 21/2% aqueous NaOH solution. The basic extracts were acidified yielding a precipitate of ethyl 6-methyl-5-phenyl-4-oxonicotinate. Recrystallization of this material from methylene chloride/ether provided 12.3 g. of white solid, m.p.=178°-180° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04714492 |
| 출처 데이터셋 | uspto-grants-1987_12 |
| ORD ID | ord-23a95f131ca541c58acac5abcdae4608 |
| 출처 메모 | uspto-grants-1987_12 |