Sulfuryl chloride → 6-Amino-5,7-Dichloro-2-Methylbenzoxazole

HRID 9866

반응식

HRID 9866 반응식
[NH2:1][C:2]1[C:11]([Cl:12])=[CH:10][C:5]2[N:6]=[C:7]([CH3:9])[O:8][C:4]=2[CH:3]=1.S(Cl)([Cl:16])(=O)=O>C(OCC)(=O)C>[NH2:1][C:2]1[C:11]([Cl:12])=[CH:10][C:5]2[N:6]=[C:7]([CH3:9])[O:8][C:4]=2[C:3]=1[Cl:16]

참가 물질

4

반응물 2

HCID 24648Sulfuryl chlorideHCID 112754042-Methyl-5-chloro-6-benzoxazolamine

생성물 1

HCID 219887696-Amino-5,7-Dichloro-2-Methylbenzoxazole

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

6-Amino-5-chloro-2-methylbenzoxazole (10 g, 54.76 mMole) was dissolved in ethyl acetate (150 mL). At room temperature and with good stirring, sulfuryl chloride (8.8 mL, 109.52 mMole) was added drop by drop over a 20-minute period. As the addition proceeds, additional ethyl acetate (350 mL) was added to keep the mixture stirring. After 1 hour the precipitate was filtered off, washed with ether and air-dried. Yield 10.5 g.

후처리

  1. additionwas added
  2. filtrationAfter 1 hour the precipitate was filtered off
  3. washwashed with ether
  4. customair-dried

출처 및 근거

ORD 기록
ord-e1a8a1d4fea343c68da40b757c689dec
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091361B2

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