Fluoroacetyl chloride → N-(2-fluoroacetamido-5-nitrobenzoyl)-2-methyl-4-fluoroaniline

HRID 986654

반응식

HRID 986654 반응식
[NH2:1][C:2]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:8]=1[CH3:14])=[O:5].[F:22][CH2:23][C:24](Cl)=[O:25]>N1C=CC=CC=1>[F:22][CH2:23][C:24]([NH:1][C:2]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:8]=1[CH3:14])=[O:5])=[O:25]

참가 물질

4

반응물 2

HCID 9663Fluoroacetyl chlorideHCID 13376450HCID 13376450, 화합물

생성물 1

HCID 13376458N-(2-fluoroacetamido-5-nitrobenzoyl)-2-methyl-4-fluoroaniline수율 84.9%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

3.9 g of N-(2-amino-5-nitrobenzoyl)-2-methyl-4-fluoroaniline, 1.6 g of pyridine and 1.96 g of fluoroacetyl chloride are treated in the same manner as described in Example 1-(1), whereby 4.0 g of N-(2-fluoroacetamido-5-nitrobenzoyl)-2-methyl-4-fluoroaniline are obtained as colorless needles.

출처 및 근거

ORD 기록
ord-f34f851317ce42428e32186aebcd1f37
출처 데이터셋
uspto-grants-1987_12
특허 번호
US04714702

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