Thionyl Chloride → 2-[(4-Dodecyloxyphenyl)sulfonyl]butanoyl Chloride

HRID 9867노트

반응식

HRID 9867 반응식
[CH2:1]([O:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([CH:23]([CH2:27][CH3:28])[C:24](O)=[O:25])(=[O:22])=[O:21])=[CH:16][CH:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].S(Cl)([Cl:31])=O>C(OCC)(=O)C.CN(C)C=O>[CH2:1]([O:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([CH:23]([CH2:27][CH3:28])[C:24]([Cl:31])=[O:25])(=[O:22])=[O:21])=[CH:16][CH:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 155390142-[(4-Dodecyloxyphenyl)sulfonyl]butanoic acid

생성물 1

HCID 155390152-[(4-Dodecyloxyphenyl)sulfonyl]butanoyl Chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 8857Ethyl Acetate용매

반응 조건

온도
70 °C

실험 절차

2-[(4-Dodecyloxyphenyl)sulfonyl]butanoic acid (19.5 g, 47.33 mMole) was suspended in ethyl acetate (150 mL) to which was added several drops of dimethylformamide and thionyl chloride (14.4 mL, 119 mMole). The mixture was heated at 70° C. for 1.5 hours, cooled, concentrated under reduced pressure, co-evaporated with ethyl acetate (2×100 mL) and the oil so obtained used as such in the next step of the reaction sequence.

후처리

  1. temperaturecooled
  2. concentrationconcentrated under reduced pressure, co-evaporated with ethyl acetate (2×100 mL)
  3. customthe oil so obtained

출처 및 근거

ORD 기록
ord-bd37e20faae04c81914e2285bd65c7dd
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091361B2

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