1-(4-Nitrophenyl)-1H-imidazole → 4-(1H-imidazol-1-yl)aniline

HRID 987037

반응식

HRID 987037 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[CH:8][CH:9]=1

참가 물질

4

반응물 1

HCID 1231551-(4-Nitrophenyl)-1H-imidazole

생성물 1

HCID 3201654-(1H-imidazol-1-yl)aniline수율 89%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

1-(4-nitrophenyl)-1H-imidazole (4.4 g; 23.5 mmoles) is put in solution in anhydrous methanol (140 ml) and palladium on carbon (0.44 g) is added to the medium. The reaction medium is placed under hydrogen for 4 hours. The catalyst is filtered off and the solvent is evapored to dryness. The expected product is obtained in a virtually pure state with a yield of 89% (3.3 g).

후처리

  1. filtrationThe catalyst is filtered off

출처 및 근거

ORD 기록
ord-c0e84999a77543029924f17e5950f698
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06630461B2

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