2,4-Dioxo-3-(4-phenylbutyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-carboxylic Acid Benzyl Ester → 3-(4-Phenylbutyl)-3,9-diaza-bicyclo[3.3.1]nonane-2,4-dione

HRID 987087노트

반응식

HRID 987087 반응식
C(OC([N:11]1[CH:16]2[CH2:17][CH2:18][CH2:19][CH:12]1[C:13](=[O:31])[N:14]([CH2:21][CH2:22][CH2:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:15]2=[O:20])=O)C1C=CC=CC=1.[H][H]>C1COCC1.[Pd]>[C:25]1([CH2:24][CH2:23][CH2:22][CH2:21][N:14]2[C:15](=[O:20])[CH:16]3[NH:11][CH:12]([CH2:19][CH2:18][CH2:17]3)[C:13]2=[O:31])[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

참가 물질

5

반응물 2

HCID 537413262,4-Dioxo-3-(4-phenylbutyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-carboxylic Acid Benzyl Ester2회HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 229879053-(4-Phenylbutyl)-3,9-diaza-bicyclo[3.3.1]nonane-2,4-dione수율 92.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

2,4-Dioxo-3-(4-phenylbutyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-carboxylic acid benzyl ester (Compound 13, 0.57 g, 1.36 mmol) was dissolved in THF (3 mL), and 10% palladium on activated carbon (0.12 g) was added. Hydrogen was applied via balloon for 1 hour. The black suspension was then filtered through compacted Celite, and the THF was removed by high-vacuum rotary evaporator to give Compound 14 (0.36 g, 92%) as a thick oil, which was of sufficiently good quality to be advanced to the next step without further purification.

후처리

  1. filtrationThe black suspension was then filtered
  2. customthe THF was removed by high-vacuum rotary evaporator

출처 및 근거

ORD 기록
ord-bce372b42ea744fd83e0f4949e6387d1
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06630472B1

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