Octahydroindolizin-7-one → Octahydroindolizin-7-amine

HRID 9872

반응식

HRID 9872 반응식
[CH2:1]1[CH:9]2[N:4]([CH2:5][CH2:6][C:7](=O)[CH2:8]2)[CH2:3][CH2:2]1.[NH3:11].C(O)C.[H][H]>[Pd]>[NH2:11][CH:7]1[CH2:8][CH:9]2[N:4]([CH2:3][CH2:2][CH2:1]2)[CH2:5][CH2:6]1

참가 물질

5

반응물 3

HCID 11240524Octahydroindolizin-7-oneHCID 22020343Ethanol, reaction products with ammonia, distn. residuesHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 21988494Octahydroindolizin-7-amine수율 98%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

(±)-1,2,3,5,6,7,8,8a-octahydroindolizin-7-one (5.0 g, 35.9 mmol) was dissolved in a solution of 2M ammonia/ethanol (54 ml, 108 mmol calculated in terms of ammonia). The resulting solution was stirred at room temperature in an atmosphere of hydrogen in the presence of 10% palladium on charcoal (500 mg) for 4 hours. At the end of this time, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated by evaporation under reduced pressure, to give the title compound (4.91 g) as a colorless oil (yield 98%).

후처리

  1. filtrationAt the end of this time, the reaction mixture was filtered
  2. customto remove the catalyst
  3. concentrationthe filtrate was concentrated by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-d4445a4fa7c3408b8f17654f35a6a381
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091352B2

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