HCID 53643183, 화합물 → HCID 22988045, 화합물
반응식
[CH3:1][O:2][C:3](=[O:21])[CH:4]([NH:14][C:15]1[N:20]=[CH:19][CH:18]=[CH:17][N:16]=1)[CH2:5][NH:6]C(OC(C)(C)C)=O>Cl.O1CCOCC1>[CH3:1][O:2][C:3](=[O:21])[CH:4]([NH:14][C:15]1[N:16]=[CH:17][CH:18]=[CH:19][N:20]=1)[CH2:5][NH2:6]참가 물질
3
실험 절차
A solution of 3-tert-butoxycarbonylamino-2-(pyrimidin-2-ylamino)-propionic acid methyl ester (227 mg, 0.77 mmol) in HCl/dioxane (4 N, 5 mL) was stirred at room temperature for 1 hour. The solution was then concentrated to dryness and the residue was dissolved in water (20 mL). This solution was then washed with dichloromethane (2×10 mL) and hexanes (10 mL). The solution was then filtered and lyophilized to yield (+/−)-3-amino-2-(pyrimidin-2-ylamino)-propionic acid methyl ester as a yellow solid (185 mg, 90%).
후처리
- concentrationThe solution was then concentrated to dryness
- dissolutionthe residue was dissolved in water (20 mL)
- washThis solution was then washed with dichloromethane (2×10 mL) and hexanes (10 mL)
- filtrationThe solution was then filtered
출처 및 근거
- ORD 기록
- ord-288349d5ca4c45da97e8b640fa73a6c3
- 출처 데이터셋
- uspto-grants-2003_10
- 특허 번호
- US06630488B1
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