Water → 2-Ethoxy-3-(4-hydroxy-2-nitrophenyl)propanoic acid methyl ester

HRID 987266노트

반응식

HRID 987266 반응식
[CH3:1][O:2][C:3](=[O:26])[CH:4]([O:23][CH2:24][CH3:25])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12]CC2C=CC=CC=2)=[CH:8][C:7]=1[N+:20]([O-:22])=[O:21].CSC.B(F)(F)F.CCOCC.O>ClCCl>[CH3:1][O:2][C:3](=[O:26])[CH:4]([O:23][CH2:24][CH3:25])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]=1[N+:20]([O-:22])=[O:21]

참가 물질

6

반응물 4

HCID 962WaterHCID 1068Dimethyl SulfideHCID 8000Boron trifluoride etherateHCID 538566552-Ethoxy-3-(4-benzyloxy-2-nitrophenyl)propanoic acid methyl ester

생성물 1

HCID 538988402-Ethoxy-3-(4-hydroxy-2-nitrophenyl)propanoic acid methyl ester수율 95.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

2-Ethoxy-3-(4-benzyloxy-2-nitrophenyl)propanoic acid methyl ester (1.5 g; 4.06 mmole) was dissolved in dichloromethane (8 ml) and dimethylsulfide (8 ml) was added. Boron trifluoride diethyl etherate (5.0 ml; 40.6 mmole) was added under stirring. The reaction mixture was stirred at room temperature for 4 hours and then poured into water and more dichloromethane was added. The phases were separated and the organic phase was washed with water and brine and dried with magnesium sulfate. Evaporation to remove the solvent gave 1.04 g (95% yield) of 2-ethoxy-3-(4-hydroxy-2-nitrophenyl)propanoic acid methyl ester.

후처리

  1. stirringThe reaction mixture was stirred at room temperature for 4 hours
  2. additionwas added
  3. customThe phases were separated
  4. washthe organic phase was washed with water and brine
  5. dry with materialdried with magnesium sulfate
  6. customEvaporation
  7. customto remove the solvent

출처 및 근거

ORD 기록
ord-61bb798f6fec47ba9c11000f3914bff2
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06630600B1

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