Potassium Hydroxide → 5,6,7-Trimethoxy-1H-indole-2-carboxylic acid

HRID 987436

반응식

HRID 987436 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([O:18]C)=[O:17])=[CH:6]2.[OH-].[K+]>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([OH:18])=[O:17])=[CH:6]2

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 4453649methyl 5,6,7-trimethoxy-1H-indole-2-carboxylate

생성물 1

HCID 8210525,6,7-Trimethoxy-1H-indole-2-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl 5,6,7-trimethoxyindole-2-carboxylate (700 mg) was dissolved in methanol (13 mL), potassium hydroxide powder (450 mg) was added to the solution, and the mixture was stirred for 3 hours under reflux. After allowing the reaction mixture to cool, it was concentrated under reduced pressure, and water was added to the residue. The resultant water layer was washed with ether and then neutralized with diluted hydrochloric acid. Crystals deposited were collected by filtration and dried to obtain the title compound.

후처리

  1. temperatureunder reflux
  2. temperatureto cool
  3. concentrationit was concentrated under reduced pressure, and water
  4. additionwas added to the residue
  5. washThe resultant water layer was washed with ether
  6. filtrationCrystals deposited were collected by filtration
  7. customdried

출처 및 근거

ORD 기록
ord-1b5e7a8bd55d4111a545f175c53f3e98
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06632810B2

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