Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Aminophenol → 4-(4-Hydroxyanilino)-6-chloropyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Aminophenol | HCID 403 | — |
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 4,6-Dichloropyrimidine | HCID 70943 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 4-(4-Hydroxyanilino)-6-chloropyrimidine | HCID 18009128 | 69.4% |
반응 단계
To a solution of 4,6-dichloropyrimidine (24.8 g), ethanol (250 ml) and triethylamine (51 ml) was added 4-aminophenol (18.2 g) and the solution was heated at reflux for 6 hours. After cooling the precipitate was collected, washed with DCM (100 ml) and recrystallized in acetonitrile to give the title compound (25.6 g, 69%) as crystals. NMR: 6.59 (1H, s), 6.73 (2H, d), 7.28 (2H, d), 8.33 (1H, s), 9.28 (1H, s), 9.52 (1H, s); m/z 222 (NH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06632820B1 |
| 출처 데이터셋 | uspto-grants-2003_10 |
| ORD ID | ord-d5962015454f46a583da5de41423fa0f |
| 출처 메모 | uspto-grants-2003_10 |