Dimethyl acetylenedicarboxylate → HCID 178499652, 화합물
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH2:12])=[S:11].[C:13]([C:19](OC)=[O:20])#[C:14][C:15]([O:17][CH3:18])=[O:16]>CO>[CH3:18][O:17][C:15](=[O:16])[CH:14]=[C:13]1[S:11][C:10]([NH:9][C:3]2[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][C:4]=2[Cl:8])=[N:12][C:19]1=[O:20]참가 물질
4
반응 조건
- 온도
- 25 °C
실험 절차
2,6-Dichlorophenylthiourea (3.0 g, 13.6 mmol) was dissolved in 50 mL of dry methanol and dimethyl acetylenedicarboxylate (13.8 mmol, 1.7 mL) was added over a 10-minute period. The mixture was stirred at 25° C. for 40 minutes, then the mixture was heated at 55° C. for 3 hours. The solvent was removed by rotvap, and the crude product was recrystallized from methanol to yield the desired product.
후처리
- temperaturethe mixture was heated at 55° C. for 3 hours
- customThe solvent was removed by rotvap
- customthe crude product was recrystallized from methanol
출처 및 근거
- ORD 기록
- ord-47ab7d127d864fd887dbef69ec9c27e4
- 출처 데이터셋
- uspto-grants-2003_10
- 특허 번호
- US06632831B2
반응 노트
불러오는 중…