Nitric Acid → 2,4,6-Trimethyl-3-nitrobenzoic acid

HRID 987846노트

반응식

HRID 987846 반응식
[CH3:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([CH3:12])[C:3]=1[C:4]([OH:6])=[O:5].[N+:13]([O-])([OH:15])=[O:14]>>[N+:13]([C:10]1[C:2]([CH3:1])=[C:3]([C:7]([CH3:12])=[CH:8][C:9]=1[CH3:11])[C:4]([OH:6])=[O:5])([O-:15])=[O:14]

참가 물질

3

반응물 2

HCID 944Nitric AcidHCID 101942,4,6-Trimethylbenzoic acid

생성물 1

HCID 81670772,4,6-Trimethyl-3-nitrobenzoic acid수율 94%

실험 절차

To a suspension of 2,4,6-trimethylbenzoic acid (4.6 g, 28 mmol) in 70% HNO3 (85 mL) conc. H2SO4 (5 mL). was added dropwise at RT. The brown reaction mixture was stirred for 1 h, poured into ice-water (500 mL). The product was extracted into ethyl acetate, the extract was washed with water, dried over MgSO4 and concentrated to give 3-nitro-2,4,6-trimethylbenzoic acid as a yellow solid (6.7 g, 94%).

후처리

  1. additionwas added dropwise at RT
  2. extractionThe product was extracted into ethyl acetate
  3. washthe extract was washed with water
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5bbccd3583664f3b86f56fdba47345ce
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06632829B2

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