2-(4-Benzyloxy-3-propoxyphenyl)-5,5-dimethyl-1,3-dioxane → HCID 22987076, 화합물

HRID 987869노트

반응식

HRID 987869 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[O:20][CH2:19][C:18]([CH3:22])([CH3:21])[CH2:17][O:16]2)=[CH:11][C:10]=1[O:23][CH2:24][CH2:25][CH3:26])C1C=CC=CC=1>[Pd].O1CCCC1>[CH3:21][C:18]1([CH3:22])[CH2:17][O:16][CH:15]([C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([O:23][CH2:24][CH2:25][CH3:26])[CH:11]=2)[O:20][CH2:19]1

참가 물질

4

반응물 1

HCID 229870842-(4-Benzyloxy-3-propoxyphenyl)-5,5-dimethyl-1,3-dioxane

생성물 1

HCID 22987076HCID 22987076, 화합물수율 98.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 1.07 g (3.00 mmol) of 2-(4-benzyloxy-3-propoxyphenyl)-5,5-dimethyl-1,3-dioxane, 15 ml of tetrahydrofuran and 107 g of 10% palladium/C hydrogenation catalyst was hydrogenated at room temperature. After the absorption of 62.4 ml of hydrogen, the reaction suspension was filtered through Dicalite and evaporated down. Chromatography of the residue over 25 g of silica gel using 19:1 toluene/ethyl acetate gave 790 mg of 4-(5,5-dimethyl-1,3-dioxan-2-yl)-2-propoxyphenol.

후처리

  1. customwas hydrogenated at room temperature
  2. customAfter the absorption of 62.4 ml of hydrogen
  3. filtrationthe reaction suspension was filtered through Dicalite
  4. customevaporated down

출처 및 근거

ORD 기록
ord-a94e7249634744398b4e399e10a46b1a
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06632909B2

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