Toluene → 4-Hydroxy-3-propoxybenzaldehyde

HRID 987870노트

반응식

HRID 987870 반응식
CC1(C)CO[CH:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([O:15][CH2:16][CH2:17][CH3:18])[CH:9]=2)[O:4]C1.C1(C)C=CC=CC=1>C(O)=O>[OH:14][C:11]1[CH:12]=[CH:13][C:8]([CH:5]=[O:4])=[CH:9][C:10]=1[O:15][CH2:16][CH2:17][CH3:18]

참가 물질

4

반응물 2

HCID 1140TolueneHCID 22987076HCID 22987076, 화합물

생성물 1

HCID 17126234-Hydroxy-3-propoxybenzaldehyde수율 0.1%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

A mixture of 1.26 g (4.74 mmol) of 4-(5,5-dimethyl-1,3-dioxan-2-yl)-2-propoxyphenol, 20 ml of toluene and 20 ml of formic acid was vigorously stirred for 2 hours at room temperature. Thereafter, the reaction mixture was partitioned between toluene and water and the organic phase was washed several times with water, dried over magnesium sulfate, filtered and evaporated down. Crystallization of the residue from a mixture of 10 ml of diethyl ether and 20 ml of hexane gave 0.78 mg of 4-hydroxy-3-propoxybenzaldehyde.

후처리

  1. customThereafter, the reaction mixture was partitioned between toluene and water
  2. washthe organic phase was washed several times with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated down
  6. customCrystallization of the residue
  7. additionfrom a mixture of 10 ml of diethyl ether and 20 ml of hexane

출처 및 근거

ORD 기록
ord-22979cd9413c4b5fa6b09df8a67e6f1c
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06632909B2

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