HCID 514003, 화합물 → HCID 514034, 화합물

HRID 987996노트

반응식

HRID 987996 반응식
[NH2:1][C@@H:2]([CH2:29][C:30]1[CH:39]=[CH:38][C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:31]=1)[C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][C@H:10]([N:13]([S:18]([C:21]1[CH:26]=[CH:25][C:24]([F:27])=[C:23]([NH2:28])[CH:22]=1)(=[O:20])=[O:19])[CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:11][OH:12])=[O:4].[NH:40]1[CH:44]=[C:43]([C:45](O)=[O:46])[N:42]=[CH:41]1>>[NH2:28][C:23]1[CH:22]=[C:21]([S:18]([N:13]([CH2:14][CH:15]([CH3:16])[CH3:17])[C@H:10]([CH2:11][OH:12])[CH2:9][CH2:8][CH2:7][CH2:6][NH:5][C:3]([C@@H:2]([NH:1][C:45]([C:43]2[NH:42][CH:41]=[N:40][CH:44]=2)=[O:46])[CH2:29][C:30]2[CH:39]=[CH:38][C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:31]=2)=[O:4])(=[O:19])=[O:20])[CH:26]=[CH:25][C:24]=1[F:27]

참가 물질

3

반응물 2

HCID 514003HCID 514003, 화합물HCID 178524800HCID 178524800, 화합물

생성물 1

HCID 514034HCID 514034, 화합물

실험 절차

The title compound was prepared from (2S,5S)-2-amino-N-{5-[(3-amino-4-fluoro-benzenesulfonyl)-isobutyl-amino]-6-hydroxy-hexyl}-3-naphthalen-2-yl-propionamide (example 81) as described in general procedure E using 4-imidazolecarboxylic acid. The final product was obtained in 20% yield.

출처 및 근거

ORD 기록
ord-156d3e6c685c4c4ea5a77c3d6c769b0c
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06632816B1

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