4-Chloropyridine-2-carboxylic acid → HCID 21906537, 화합물

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:28])[C:10]2[CH:15]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[CH:13]=[CH:12][C:11]=2[NH:20][CH2:21][CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[N:6][CH:7]=1.Cl[C:30]1[CH:35]=[CH:34][N:33]=[C:32]([C:36]([OH:38])=[O:37])[CH:31]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:28])[C:10]2[CH:15]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[CH:13]=[CH:12][C:11]=2[NH:20][CH2:21][CH:22]2[CH2:27][CH2:26][N:25]([C:30]3[CH:35]=[CH:34][N:33]=[C:32]([C:36]([OH:38])=[O:37])[CH:31]=3)[CH2:24][CH2:23]2)=[N:6][CH:7]=1

참가 물질

반응물 2

HCID 2308904-Chloropyridine-2-carboxylic acid

HCID 21906567HCID 21906567, 화합물

생성물 1

HCID 21906537HCID 21906537, 화합물수율 82.5%

실험 절차

Using a similar procedure to that described in Example 52, N-(5-chloropyridin-2-yl)-5-methoxycarbonyl-2-[(4-piperidinylmethyl)amino]benzamide (0.30 g, 0.74 mmol) and 4-chloropicolinic acid (0.23 g, 1.5 mmol) afforded 320 mg (82%) of the title compound.

출처 및 근거

ORD 기록: ord-7616152156fd403ba8b56730766069b9
출처 데이터셋: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06635657B1

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