2-Bromo-1-(3-nitrophenyl)ethan-1-one → 4-(3-Nitrophenyl)-2-(3-pyridyl)-thiazole hydrobromide
반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=1)=O.[C:14]([NH2:22])(=[S:21])[C:15]1[CH:20]=[CH:19][CH:18]=[N:17][CH:16]=1>C(O)C>[BrH:1].[N+:11]([C:7]1[CH:6]=[C:5]([C:3]2[N:22]=[C:14]([C:15]3[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=3)[S:21][CH:2]=2)[CH:10]=[CH:9][CH:8]=1)([O-:13])=[O:12]참가 물질
4
실험 절차
A mixture of 2-bromo-3′-nitroacetophenone (5 g, 20 mmol) and thionicotinamide (2.76 g, 20 mmol) in ethanol (25 ml) was heated to reflux for 1 h, during which time extensive precipitation occurred. Filtration and drying afforded the product as a yellow solid (6.7 g, 92%).
후처리
- temperaturewas heated
- temperatureto reflux for 1 h, during which time extensive precipitation
- filtrationFiltration
- customdrying
출처 및 근거
- ORD 기록
- ord-dcdfa7ba5a9649b4987c5725033af87f
- 출처 데이터셋
- uspto-grants-2003_10
- 특허 번호
- US06638953B2
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