p-Bromobenzyl chloride → HCID 10132336, 화합물

HRID 989265

반응식

HRID 989265 반응식
[OH:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][N:7]2[CH2:11][CH2:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[Br:14][C:15]1[CH:22]=[CH:21][C:18]([CH2:19]Cl)=[CH:17][CH:16]=1>C(O)C>[Br:14][C:15]1[CH:22]=[CH:21][C:18]([CH2:19][O:1][C:2]2[CH:13]=[CH:12][C:5]([CH2:6][N:7]3[CH2:11][CH2:10][CH2:9][CH2:8]3)=[CH:4][CH:3]=2)=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 68528p-Bromobenzyl chlorideHCID 187719784-(Pyrrolidin-1-ylmethyl)phenol

생성물 1

HCID 10132336HCID 10132336, 화합물수율 57.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The mixture of 4-hydroxybenzyl-pyrrolidine (177 mg), 4-bromo-benzylchloride (205 mg), and t-Bu3ONa (192 mg) in ethanol (10 mL) was heated at 80° C. for overnight. Concentration and preparative TLC provided the title compound (200 mg). 1H NMR (400 MHz, CDCI3)δ7.50 (d, J=6.5 Hz, 2 H), 7.32 (d, J=6.5 Hz, 2 H), 7.25 (d, J=6.5 Hz, 2 H), 6.90 (d, J=6.5 Hz, 2 H), 2.84 (s, 2 H), 2.50 (m, 4 H), 1.42 (m, 4 H).

후처리

  1. concentrationConcentration and preparative TLC

출처 및 근거

ORD 기록
ord-08358f3cc91642efa4cf3897b399b0a9
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06638967B2

연결된 노트

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