Acetone → cefpodoxime sodium

HRID 989420노트

반응식

HRID 989420 반응식
C([O-])(=O)C.[Na+:5].[CH3:6][O:7][CH2:8][C:9]1[CH2:30][S:29][C@@H:12]2[C@H:13]([NH:16][C:17](/[C:19](/[C:23]3[N:27]=[C:26]([NH2:28])[S:25][CH:24]=3)=[N:20]\[O:21][CH3:22])=[O:18])[C:14](=[O:15])[N:11]2[C:10]=1[C:31]([OH:33])=[O:32].CN(C)C(=O)C.CC(C)=O>O.CO>[CH3:6][O:7][CH2:8][C:9]1[CH2:30][S:29][C@@H:12]2[C@H:13]([NH:16][C:17](/[C:19](/[C:23]3[N:27]=[C:26]([NH2:28])[S:25][CH:24]=3)=[N:20]\[O:21][CH3:22])=[O:18])[C:14](=[O:15])[N:11]2[C:10]=1[C:31]([O-:33])=[O:32].[Na+:5]

참가 물질

7

반응물 4

HCID 180AcetoneHCID 31374DimethylacetamideHCID 517045Sodium AcetateHCID 6335986Cefpodoxime

생성물 1

HCID 23669317cefpodoxime sodium수율 96%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

1.01 g of sodium acetate was dissolved in a mixture of 1 ml of water and 5 ml of methanol, and 5.0 g of cefpodoxime was added thereto, followed by addition of 15 ml of N,N-dimethylacetamide. The mixture was stirred at room temperature for 30 minutes and then, 100 ml of acetone was added thereto. The solution was stirred for 20 minutes and filtered. The filtered solid was washed with 50 ml of acetone and then with 30 ml of isopropyl ether, and vacuum-dried at room temperature to give 5.04 g of pale yellow cefpodoxime sodium salt (yield: 96%).

후처리

  1. additionwas added
  2. stirringThe solution was stirred for 20 minutes
  3. filtrationfiltered
  4. washThe filtered solid was washed with 50 ml of acetone
  5. dry with materialwith 30 ml of isopropyl ether, and vacuum-dried at room temperature

출처 및 근거

ORD 기록
ord-bc90c490d620440cab7eef9ecb548d4b
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06639068B1

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