(2H-1,3-benzodioxol-5-yl)boronic acid → HCID 23445436, 화합물

HRID 990054노트

반응식

HRID 990054 반응식
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][C:3]=2[O:2]1.Br[C:14]1[CH:18]=[CH:17][S:16][C:15]=1[S:19]([N:22]1[CH:26]=[CH:25][CH:24]=[CH:23]1)(=[O:21])=[O:20]>>[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([C:14]3[CH:18]=[CH:17][S:16][C:15]=3[S:19]([N:22]3[CH:26]=[CH:25][CH:24]=[CH:23]3)(=[O:20])=[O:21])=[CH:4][C:3]=2[O:2]1

참가 물질

3

반응물 2

HCID 2734371(2H-1,3-benzodioxol-5-yl)boronic acidHCID 234455281-[(3-Bromo-2-thienyl)sulfonyl]-1H-pyrrole

생성물 1

HCID 23445436HCID 23445436, 화합물수율 90%

실험 절차

N-{[3-(3,4-Methylenedioxy)phenyl]thiophene-2-sulfonyl}pyrrole was prepared in the same manner as described in Example 13C using 3,4-methylenedioxyphenylboronic acid and N-(3-bromothiophene-2-sulfonyl)pyrrole. The crude product was purified by flash column chromatography on silica gel using 2% EtOAc in hexane as the eluent resulting in N-{[3-(3,4-methylenedioxy)phenyl]thiophene-2-sulfonyl}-pyrrole in a 90% yield.

후처리

  1. customThe crude product was purified by flash column chromatography on silica gel using 2% EtOAc in hexane as the eluent
  2. customresulting in N-{[3-(3,4-methylenedioxy)phenyl]thiophene-2-sulfonyl}-pyrrole in a 90% yield

출처 및 근거

ORD 기록
ord-7c32781afa964dd9bedd5bcfdd219681
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06458805B2

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