Nitric Acid → 1-Acetoxy-2-[(3,4-methylenedioxy)-6-nitrophenyl]ethane

HRID 990070

반응식

HRID 990070 반응식
[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]2[O:13][CH2:14][O:15][C:9]=2[CH:8]=1)(=[O:3])[CH3:2].[N+:16]([O-])([OH:18])=[O:17].O>C(O)(=O)C>[C:1]([O:4][CH2:5][CH2:6][C:7]1[C:12]([N+:16]([O-:18])=[O:17])=[CH:11][C:10]2[O:13][CH2:14][O:15][C:9]=2[CH:8]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 962WaterHCID 3030742-(1,3-Benzodioxol-5-yl)ethyl acetate

생성물 1

HCID 234454281-Acetoxy-2-[(3,4-methylenedioxy)-6-nitrophenyl]ethane수율 88%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a stirred solution of 1-acetoxy-2-[(3,4-methylenedioxy)-phenyl]ethane (1.7 g, 8.09 mmol) in acetic acid (10 mL) was added, dropwise, concentrated HNO3 (4.5 mL). This was stirred at room temperature for 30 min. The reaction mixture was poured into water (100 mL). The precipitated solid was filtered, washed with water and dried under high vacuum to afford 1-acetoxy-2-[(3,4-methylenedioxy)-6-nitrophenyl]ethane (1.8 g, 88% yield).

후처리

  1. filtrationThe precipitated solid was filtered
  2. washwashed with water
  3. customdried under high vacuum

출처 및 근거

ORD 기록
ord-bc49a2cc0b734445bb4df2f685fd3820
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06458805B2

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