HCID 2800136, 화합물 → 6-(4-chloro-2-methylphenoxy)pyridin-3-amine

HRID 990180노트

반응식

HRID 990180 반응식
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][N:8]=2)=[C:4]([CH3:18])[CH:3]=1.[H][H]>C(O)C.[OH-].[OH-].[Pd+2]>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][N:8]=2)=[C:4]([CH3:18])[CH:3]=1

참가 물질

5

반응물 2

HCID 2800136HCID 2800136, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 28001436-(4-chloro-2-methylphenoxy)pyridin-3-amine

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

2-(4-chloro-2-methyl-phenoxy)-5-nitropyridine (203 mg, 0.77 mmol) was dissolved in 95% ethanol (3 mL) and treated with 20% palladium hydroxide on carbon (50 mg). The reaction mixture was shaken in a hydrogen atmosphere (40 psi) for 1 hour. The solution was filtered through celite and concentrated in vacuo . MS (m/z): 234/236 (M+H)+; C12H11N2OCl requires 234.7.

후처리

  1. filtrationThe solution was filtered through celite and
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-3429fb8f04d740daa2e80dde4329c090
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06458813B1

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