Diisopropyl diazene-1,2-dicarboxylate → Ethyl 5-[1-(2,2,2-trifluoro-ethyl)-piperidin-4-yloxy]-1H-indole-2-carboxylate

반응식

[F:16][C:17]([CH2:18][N:19]1[CH2:20][CH2:21][CH:22]([OH:25])[CH2:23][CH2:24]1)([F:26])[F:27].[O:28]=[C:29]([O:30][CH:31]([CH3:32])[CH3:33])[N:34]=[N:35][C:36]([O:37][CH:38]([CH3:39])[CH3:40])=[O:41].[OH:1][c:2]1[cH:3][c:4]2[cH:5][c:6]([C:11](=[O:12])[O:13][CH2:14][CH3:15])[nH:7][c:8]2[cH:9][cH:10]1>>[O:1]([c:2]1[cH:3][c:4]2[cH:5][c:6]([C:11](=[O:12])[O:13][CH2:14][CH3:15])[nH:7][c:8]2[cH:9][cH:10]1)[CH:22]1[CH2:21][CH2:20][N:19]([CH2:18][C:17]([F:16])([F:26])[F:27])[CH2:24][CH2:23]1

참가 물질

반응물 3

HCID 75555Diisopropyl diazene-1,2-dicarboxylate

HCID 90677Ethyl 5-hydroxy-1H-indole-2-carboxylate

HCID 434262781-(2,2,2-Trifluoroethyl)piperidin-4-ol

생성물 1

HCID 68565990Ethyl 5-[1-(2,2,2-trifluoro-ethyl)-piperidin-4-yloxy]-1H-indole-2-carboxylate

출처 및 근거

ORD 기록: ord-806225cbae8249e7966a36da4370df65
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

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