Acetone → Ethyl 2-[(4-ethoxyphenyl)sulfanyl]propanoate

HRID 991037노트

반응식

HRID 991037 반응식
[CH2:1]([O:3][C:4](=[O:15])[CH:5]([S:7][C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1)[CH3:6])[CH3:2].C([O-])([O-])=O.[K+].[K+].[CH3:22][C:23](C)=O>>[CH2:1]([O:3][C:4](=[O:15])[CH:5]([S:7][C:8]1[CH:9]=[CH:10][C:11]([O:14][CH2:22][CH3:23])=[CH:12][CH:13]=1)[CH3:6])[CH3:2]

참가 물질

4

반응물 3

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 109771882-[(4-Hydroxyphenyl)thio]propanoic acid ehtyl ester

생성물 1

HCID 10934051Ethyl 2-[(4-ethoxyphenyl)sulfanyl]propanoate

실험 절차

To stired solution of 2-(4-hydroxy-phenylsulfanyl)-propionic acid ethyl ester (11.3 g, 50 mmol), and K2CO3 (50 g, excess) in acetone (300 ml) ethyl iodide (20 ml, excess) was added and refluxed for 8 hrs. At the end, reaction mixture was filtered and concentrated. The residue obtained was extracted with chloroform and washed well with water. It was dried and concentrated. The product, 2-(4-ethoxy-phenylsulfanyl)-propionic acid ethyl ester was isolated as colorless oil. Yield: 12.0 g, 98%; MS: 255 (M+H).

후처리

  1. temperaturerefluxed for 8 hrs
  2. customAt the end, reaction mixture
  3. filtrationwas filtered
  4. concentrationconcentrated
  5. customThe residue obtained
  6. extractionwas extracted with chloroform
  7. washwashed well with water
  8. customIt was dried
  9. concentrationconcentrated

출처 및 근거

ORD 기록
ord-82cc8cd8350b432ab3f6529470e2b200
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06462073B2

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