1,3-Cyclohexanedione, 2-acetyl-5,5-dimethyl- → HCID 178475056, 화합물

HRID 991151

반응식

HRID 991151 반응식
[C:1]([NH:4][C@@H:5]1[C@@H:10]([O:11][C:12](=[O:14])[CH3:13])[C@H:9]([O:15][C:16](=[O:18])[CH3:17])[C@@H:8]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[O:7][C@H:6]1[NH2:24])(=[O:3])[CH3:2].[CH3:25][C:26]([CH:28]1[C:34](=[O:35])[CH2:33][C:32]([CH3:37])([CH3:36])[CH2:31][C:29]1=[O:30])=O>CO>[C:1]([NH:4][C@@H:5]1[C@@H:10]([O:11][C:12](=[O:14])[CH3:13])[C@H:9]([O:15][C:16](=[O:18])[CH3:17])[C@@H:8]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[O:7][C@H:6]1[NH:24][C:26](=[C:28]1[C:34](=[O:35])[CH2:33][C:32]([CH3:37])([CH3:36])[CH2:31][C:29]1=[O:30])[CH3:25])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 5194481,3-Cyclohexanedione, 2-acetyl-5,5-dimethyl-HCID 108933592-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-beta-D-glucopyranosylamine

생성물 1

HCID 178475056HCID 178475056, 화합물수율 60%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosyl amine (80 mg, 0.23 mmol) and 2-acetyldimedone (55 mg, 0.30 mmol) in MeOH (5 ml) was refluxed for 5 h. The reaction mixture was evaporated, the residue was purified by chromatography using CHCl3/MeOH 10:0.5 as the mobile phase, to give 2-Acetamido-3,4,6-tri-O-acetyl-1,2-dideoxy-1-[1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethylamino]-β-D-glucopyranose (19) (70 mg, 60%).

후처리

  1. temperaturewas refluxed for 5 h
  2. customThe reaction mixture was evaporated
  3. customthe residue was purified by chromatography

출처 및 근거

ORD 기록
ord-c83313feaa6a46669c5c196c4c767541
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06462183B1

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