An estradiol/methyltestosterone pressure-sensitive adhesive mixture was prepared by combining 4.0 parts of methyltestosterone and 1.1 parts of estradiol in a solution of 42.3 parts of CAB-381-0.1 with 38.0 parts each of isopropyl alcohol and ethyl acetate. Then 76.5 parts of a polysiloxane adhesive (BIO-PSA® Q7-4502, a silicone in ethyl acetate; Dow Corning Corporation, Medical Products, Midland, Mich.), 48.8 parts of a polyacrylate adhesive (DURO-TAK® 87-2510, an acrylate copolymer in ethyl acetate and hexane; National Starch and Chemical Corporation, Bridgewater, N.J.), 8.0 parts of dipropylene glycol and 6.0 parts of oleyl alcohol were added and thoroughly mixed in an appropriate container until the mixture was completely homogeneous. The resulting composition had the ingredient concentrations on a dry weight percent basis (i.e., after evaporation of volatile solvents) as shown below.
