Estradiol → Estradiol methyltestosterone

HRID 991390

반응식

HRID 991390 반응식
[CH3:1][C@@:2]12[C@H:12]3[CH2:13][CH2:14][C@:15]4([CH3:22])[C@:19]([OH:21])([CH3:20])[CH2:18][CH2:17][C@H:16]4[C@@H:11]3[CH2:10][CH2:9][C:8]1=[CH:7][C:5](=[O:6])[CH2:4][CH2:3]2.C[C@@]12[C@@H](O)CC[C@H]1[C@H]1[C@@H](C3C=CC(O)=CC=3CC1)CC2.C([O-])(=O)C=C.CC(O)COC(CO)C.C(O)CCCCCCC/C=C\CCCCCCCC>C(OCC)(=O)C.CCCCCC.C(O)(C)C>[CH3:22][C@@:15]12[C@@H:19]([OH:21])[CH2:18][CH2:17][C@H:16]1[C@H:11]1[C@@H:12]([C:2]3[CH:3]=[CH:4][C:5]([OH:6])=[CH:7][C:8]=3[CH2:9][CH2:10]1)[CH2:13][CH2:14]2.[CH3:1][C@@:2]12[C@H:12]3[CH2:13][CH2:14][C@:15]4([CH3:22])[C@:19]([OH:21])([CH3:20])[CH2:18][CH2:17][C@H:16]4[C@@H:11]3[CH2:10][CH2:9][C:8]1=[CH:7][C:5](=[O:6])[CH2:4][CH2:3]2

참가 물질

10

반응물 6

HCID 5757EstradiolHCID 6010MethyltestosteroneHCID 25188AcrylateHCID 328812-(2-Hydroxypropoxy)-1-propanolHCID 5284499Oleyl AlcoholHCID 178527255HCID 178527255, 화합물

생성물 1

HCID 9829635Estradiol methyltestosterone

시약·촉매·용매 3

HCID 3776Isopropanol용매HCID 8058Hexane용매HCID 8857Ethyl Acetate용매3회

실험 절차

An estradiol/methyltestosterone pressure-sensitive adhesive mixture was prepared by combining 4.0 parts of methyltestosterone and 1.1 parts of estradiol in a solution of 42.3 parts of CAB-381-0.1 with 38.0 parts each of isopropyl alcohol and ethyl acetate. Then 76.5 parts of a polysiloxane adhesive (BIO-PSA® Q7-4502, a silicone in ethyl acetate; Dow Corning Corporation, Medical Products, Midland, Mich.), 48.8 parts of a polyacrylate adhesive (DURO-TAK® 87-2510, an acrylate copolymer in ethyl acetate and hexane; National Starch and Chemical Corporation, Bridgewater, N.J.), 8.0 parts of dipropylene glycol and 6.0 parts of oleyl alcohol were added and thoroughly mixed in an appropriate container until the mixture was completely homogeneous. The resulting composition had the ingredient concentrations on a dry weight percent basis (i.e., after evaporation of volatile solvents) as shown below.

후처리

  1. additionthoroughly mixed in an appropriate container until the mixture
  2. concentrationthe ingredient concentrations
  3. customon a dry weight percent basis (i.e., after evaporation of volatile solvents)

출처 및 근거

ORD 기록
ord-84160a0d70d14e1087576ca7a0ef96f3
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06465004B1

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