Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 2-Chloro-6-(3-trifluoromethyl-phenyl-amino)-purine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| 반응물 | 2,6-Dichloropurine | HCID 5324412 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | 2-Chloro-6-(3-trifluoromethyl-phenyl-amino)-purine | HCID 21988237 | — |
반응 단계
1.9 g (10 mmol) of 2,6-dichloro-purine are stirred in 60 ml of butanol and 3 ml of DMF with 8.05 g (50 mmol) of 3-amino-benzotrifluoride at 60° C. for 3 h. On cooling, 2-chloro-6-(3-trifluoromethyl-phenyl-amino)-purine is obtained as a crystalline mass. This is filtered off and dried in vacuo; m.p. 248° C.; FAB-MS: (M+H)+=314; Rf=0.45 (CH2Cl2:methanol=95:5).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091346B1 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-c8bd4d0a66984a0e969d11562e64778e |
| 출처 메모 | uspto-grants-2006_08 |