Piperazine → HCID 22036265, 화합물
반응식
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[F:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][C:17]=1[F:18])[N:14]=[C:13](Cl)[C:12]([Cl:20])=[N:11]2>CCO>[Cl:20][C:12]1[C:13]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[N:14][C:15]2[C:10](=[CH:9][C:8]([F:7])=[C:17]([F:18])[CH:16]=2)[N:11]=1참가 물질
4
반응 조건
- 온도
- 75 °C
실험 절차
Piperazine (0.86 g, 10 mmol) was added to a stirred suspension of 6,7-difluoro-2,3-dichloroquinoxaline* (1.18 g, 5 mmol) in EtOH (50 mL) at room temperature. The mixture was heated at 75° C. for 17 h, allowed to cool and filtered to give the product as a pale yellow solid: yield 0.40 g (28%); mp 294-297° C. (dec). MS m/z 285/287 (M+H)+.
후처리
- temperatureto cool
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-b1f899f728bc49dcb4277c93b06dfce7
- 출처 데이터셋
- uspto-grants-2002_10
- 특허 번호
- US06465467B1
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