Sodium Methoxide → HCID 22036378, 화합물

HRID 991686노트

반응식

HRID 991686 반응식
Br[C:2]1[C:7]([O:8][CH2:9][CH2:10][OH:11])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][O-:13].[Na+]>CO>[OH:11][CH2:10][CH2:9][O:8][C:7]1[C:2]([O:13][CH3:12])=[N:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 220362632-[(2-Bromopyridin-3-yl)oxy]ethan-1-ol

생성물 1

HCID 22036378HCID 22036378, 화합물수율 45%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of the product obtained in Step 1 (2.33 g, 10.7 mmol) and NaOMe (0.634 mg, 11.8 mmol) in MeOH (50 mL) was refluxed overnight. The reaction mixture was filtered and concentrated. The residue was purified by column chromatography on silica, using CH2Cl2/MeOH/heptane (4:1:5) as eluent, to give 0.81 g (45%) of the title compound as a colorless oil.

후처리

  1. temperaturewas refluxed overnight
  2. filtrationThe reaction mixture was filtered
  3. concentrationconcentrated
  4. customThe residue was purified by column chromatography on silica

출처 및 근거

ORD 기록
ord-000a0d7b546a49cc933a6a158c28495c
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06465467B1

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