Isopropyl iodide → 2-chloro-9-isopropyl-6-(4-fluoro-phenyl-amino)-9H-purine

HRID 9917

반응식

HRID 9917 반응식
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[N:3]=1.C(=O)([O-])[O-].[Cs+].[Cs+].[CH:25](I)([CH3:27])[CH3:26].O1CCOCC1>C(OCC)(=O)C.CN(C=O)C.O>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:25]([CH3:27])[CH3:26])=[C:4]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=2)[N:3]=1

참가 물질

8

반응물 4

HCID 6362Isopropyl iodideHCID 10796Cesium carbonateHCID 312751,4-DioxaneHCID 219881932-Chloro-6-(4-fluoro-phenyl-amino)-purine

생성물 1

HCID 219882462-chloro-9-isopropyl-6-(4-fluoro-phenyl-amino)-9H-purine

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

A mixture comprising 1 g (3.3 mmol) of 2-chloro-6-(4-fluoro-phenyl-amino)-purine, 2.1 g (6.6 mmol) of caesium carbonate and 2 ml of isopropyl iodide is stirred in 32 ml of a mixture comprising dioxane, water and DMF in a ratio of 2:3:7 at 100° C. for 20 h. Thereafter, the reaction mixture is diluted with ethyl acetate and the organic phase is washed with water. After drying over sodium sulfate and removal of the solvent, the residue is chromatographed over silica gel (mobile phase: ethyl acetate:hexane=4:1). On concentration, 2-chloro-9-isopropyl-6-(4-fluoro-phenyl-amino)-9H-purine is obtained as a crystalline compound. m.p. 154° C.; FAB-MS: (M+H)+=306; Rf=0.2 (ethyl acetate:hexane=4:1).

후처리

  1. washthe organic phase is washed with water
  2. dry with materialAfter drying over sodium sulfate and removal of the solvent
  3. customthe residue is chromatographed over silica gel (mobile phase: ethyl acetate:hexane=4:1)
  4. concentrationOn concentration

출처 및 근거

ORD 기록
ord-aafe9cd2ac154742ae3af14c87c79dc2
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091346B1

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