Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hexane → Methyl 3-(3-oxocyclopentyl)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hexane | HCID 8058 | — |
| 반응물 | (S)-(-)-2,2'-Bis(di-p-tolylphosphino)-1, 1'-binaphthyl | HCID 4189906 | — |
| 반응물 | 3-(3-Oxo-cyclopent-1-enyl)-propionic acid methyl ester | HCID 11182843 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Methyl 3-(3-oxocyclopentyl)propanoate | HCID 301170 | 88.1% |
반응 단계
General procedure B using (S)-p-tol-BINAP and 3-(3-oxo-cyclopent-1-enyl)-propionic acid methyl ester (0.084 g, 0.5 mmol) gave, after 24 h at 0° C. and flash chromatography (4:1, then 2:1 hexane:ethyl acetate), the title compound as a clear oil (0.075 g, 88% yield). Spectroscopic data were consistent with previously reported data for this compound.15 [α]D25° C.−112° (c 1.3, CHCl3). Conversion of the title compound to the corresponding benzyl ester followed by chiral HPLC analysis (Chiracel OD column) indicated that the title compound was obtained in 91% ee.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06465664B1 |
| 출처 데이터셋 | uspto-grants-2002_10 |
| ORD ID | ord-b508e9f183bd4b45bed41e5665cebdc5 |
| 출처 메모 | uspto-grants-2002_10 |