3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole → 5-Fluoro-3-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]cyclohex-1-enyl}-1H-indole

HRID 992048노트

반응식

HRID 992048 반응식
O1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[C:17]([F:20])[CH:18]=4)[NH:13][CH:12]=3)=[CH:7][CH2:6]2)OCC1.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:34][CH2:33][N:32](C2CCC(=O)CC2)[CH2:31][CH2:30]1>>[F:20][C:17]1[CH:18]=[C:19]2[C:14](=[CH:15][CH:16]=1)[NH:13][CH:12]=[C:11]2[C:8]1[CH2:9][CH2:10][CH:5]([N:32]2[CH2:31][CH2:30][N:29]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[O:22][CH3:21])[CH2:34][CH2:33]2)[CH2:6][CH:7]=1

참가 물질

3

반응물 2

HCID 105163803-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indoleHCID 105653074-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-cyclohexanone

생성물 1

HCID 102013125-Fluoro-3-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]cyclohex-1-enyl}-1H-indole

실험 절차

This compound was prepared in the manner described above for intermediate 1c b y replacing 1,4-cyclohexanedione monoethylene ketal with 4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-cyclohexanone (1.44 g, 5 mmol). The crude mixture was used in next step without further purification.

후처리

  1. customThis compound was prepared in the manner
  2. customThe crude mixture was used in next step without further purification

출처 및 근거

ORD 기록
ord-70bd21f3897f4d518c96c736f40bdae1
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06465482B2

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