Acetic Acid → 3-(Cyanomethyl)pyridin-1-ium-1-olate

HRID 992071노트

반응식

HRID 992071 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]#[N:9])[CH:2]=1.CC(O)=[O:12].OO>O>[CH:5]1[CH:6]=[N+:1]([O-:12])[CH:2]=[C:3]([CH2:7][C:8]#[N:9])[CH:4]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 809233-Pyridineacetonitrile

생성물 1

HCID 2431673-(Cyanomethyl)pyridin-1-ium-1-olate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 3-pyridylacetonitrile (11 g, 93.1 mmol), HOAc (55 mL), and 30% H2O2 (17 mL) was heated at 95° C. overnight, and at room temperature for 72 hours. H2O (50 mL) was added to the reaction mixture and the resulting solution was concentrated. This was repeated with additional H2O (100 mL). Toluene (2×100 mL) was used to remove residual H2O, and the resulting white solid was dried under vacuum overnight affording a waxy white solid: mp 120-125° C.; MS (+) APCI m/z 135 [M+H]+.

후처리

  1. concentrationthe resulting solution was concentrated
  2. customto remove residual H2O
  3. customthe resulting white solid was dried under vacuum overnight
  4. customaffording a waxy white solid

출처 및 근거

ORD 기록
ord-4774082008964a9a8bdd475d1f7d8143
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06465482B2

반응 노트

불러오는 중…