Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → HCID 15782683, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Nitrotricyclo(3.3.1.13,7)decane-1-carboxylic acid | HCID 39239 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 15782683 | HCID 15782683 | 95% |
반응 단계
In an atmosphere of nitrogen, 10 mmole of 1-carboxy-3-nitroadamantane obtained by the method of Example 42 was dissolved in 10ml of DMF. To the mixture, 15 mmole of acetyl chloride was added dropwise over 30 minutes. The mixture was heated to begin to reflux around the conclusion of the addition. After refluxing for 2 hours, the mixture was cooled, 20 mmole of triethylamine was added, and then 11 mmole of methanol was added dropwise over 30 minutes while retaining the temperature of the mixture at 10° C. or less followed by stirring for more 2 hours. As a result, the conversion of 1-carboxy-3-nitroadamantane was 99%, and 1-methoxycarbonyl-3-nitroadamantane (yield 95%) was formed.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06468487B1 |
| 출처 데이터셋 | uspto-grants-2002_10 |
| ORD ID | ord-2797b2fbc30c4e2f9176f399c466e35e |
| 출처 메모 | uspto-grants-2002_10 |