Dimethylamine → 1-(N,N-dimethylcarbamoyl)-3-methoxycarbonyladamantane

HRID 992164노트

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HRID 992164 반응식
[CH3:1][NH:2][CH3:3].[CH3:4][O:5][C:6]([C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][C:10]([C:18]([O:20]C)=O)([CH2:11]3)[CH2:9]1)[CH2:15]2)=[O:7]>C1COCC1>[CH3:4][O:5][C:6]([C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][C:10]([C:18](=[O:20])[N:2]([CH3:3])[CH3:1])([CH2:11]3)[CH2:9]1)[CH2:15]2)=[O:7]

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 365223Dimethyl 1,3-adamantanedicarboxylate

생성물 1

HCID 184104771-(N,N-dimethylcarbamoyl)-3-methoxycarbonyladamantane수율 80%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1 mmole of 1,3-bis(methozxycarbonyl)adamantane obtained by the method of Example 84 was dissolved in 30 ml of THF. To the mixture, 0.5 mmole of dimethylamine and 0.1 mmole of aluminum chloride anhydride AlCl3 was added and reacted for 6 hours at 80° C. As a result, The conversion of 1,3-bis(methoxycarbonyl)adamantane was 90%, and 1-methoxycarbonyl-3-(N,N-dimethylcarbamoyl)adamantane (yield 80%) was formed.

후처리

  1. customreacted for 6 hours at 80° C

출처 및 근거

ORD 기록
ord-412942a19b374c38be373ab763298900
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06468487B1

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