Phosgene → 1-Isocyanato-3-nitroadamantane

HRID 992166노트

반응식

HRID 992166 반응식
[C:1](Cl)(Cl)=[O:2].[NH2:5][C:6]12[CH2:15][CH:10]3[CH2:11][CH:12]([CH2:14][C:8]([N+:16]([O-:18])=[O:17])([CH2:9]3)[CH2:7]1)[CH2:13]2>C1(C)C=CC=CC=1>[N:5]([C:6]12[CH2:13][CH:12]3[CH2:11][CH:10]([CH2:9][C:8]([N+:16]([O-:18])=[O:17])([CH2:14]3)[CH2:7]1)[CH2:15]2)=[C:1]=[O:2]

참가 물질

4

반응물 2

HCID 6371PhosgeneHCID 184104831-Amino-3-nitroadamantane

생성물 1

HCID 132376841-Isocyanato-3-nitroadamantane수율 90%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

10 mmole of 1-amino-3-nitroadamantane obtained by the method of Example 66 was dissolved in toluene (100 ml). To the resultant solution, 12 mmole of phosgene was added at the room temperature and stirred for 6 hours. As a result, The conversion of 1-amino-3-nitroadamantane was 99%, and 1-isocyanato-3-nitroadamantane (yield 90%) was formed.

출처 및 근거

ORD 기록
ord-7dcf062a33334c4996fd91fea700d3d8
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06468487B1

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