(3S)-1-(2-Phenylethyl)-3-pyrrolidinamine → (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-9-thioxanthenylcarboxamide

반응식

[CH:1]1[C:14]2[CH:13]([C:15]([OH:17])=O)[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[S:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[NH2:18][C@H:19]1[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:20]1>>[C:26]1([CH2:25][CH2:24][N:21]2[CH2:22][CH2:23][C@H:19]([NH:18][C:15]([CH:13]3[C:14]4[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=4[S:6][C:7]4[C:12]3=[CH:11][CH:10]=[CH:9][CH:8]=4)=[O:17])[CH2:20]2)[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

참가 물질

반응물 2

HCID 10774056(3S)-1-(2-Phenylethyl)-3-pyrrolidinamine

HCID 125156549H-Thioxanthene-9-carboxylic acid

생성물 1

HCID 22888080(S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-9-thioxanthenylcarboxamide

실험 절차

9-Thioxanthenylcarboxylic acid and (S)-3-amino-1-(2-phenylethyl)pyrrolidine were reacted under the same conditions as in Example 23 to give (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-9-thioxanthenylcarboxamide.

출처 및 근거

ORD 기록: ord-bb7d405c7d0b405db74f548bf3a9384d
출처 데이터셋: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06468998B1

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