Adamantane-1-sulfinyl Chloride → HCID 70173965, 화합물

HRID 992325

반응식

HRID 992325 반응식
[C:1]12([S:11](Cl)=[O:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH2:14][C@H:15]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[CH2:16]1>>[F:28][C:25]1[CH:26]=[CH:27][C:22]([CH2:21][CH2:20][N:17]2[CH2:18][CH2:19][CH:15]([NH:14][S@:11]([C:1]34[CH2:10][CH:5]5[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]5)[CH2:2]3)[CH2:8]4)=[O:12])[CH2:16]2)=[CH:23][CH:24]=1

참가 물질

3

반응물 2

HCID 4737333Adamantane-1-sulfinyl ChlorideHCID 59915932(S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine

생성물 1

HCID 70173965HCID 70173965, 화합물

실험 절차

1-Adamantanesulfinyl chloride and (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine were reacted under the same conditions as in Example 53 to give (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-1-adamantanesulfinamide.

출처 및 근거

ORD 기록
ord-cf1943ad7b2e4b71807ae69abfeba6f2
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06468998B1

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